|
Sample Record |
| DATABASE FILE: | CCRIS [Chemical Carcinogenisis Research Information System] |
| CAS REGISTRY NUMBER: | 50-07-7 |
| CHEMICAL NAME: | MITOMYCIN-C |
| MAJOR USE CLASS: | DRUGS (ANTINEOPLASTICS) |
| DATA TYPE: | Carcinogenicity; Mutagenicity; Tumor Inhibition |
| PUBLICATION YEAR: | 1997 |
| CARCINOGENECITY/MUTAGENECITY: |
Carcinogenicity Studies
Species : RAT
Route : INTRAPERITONEAL
Tumor Site: Type of Lesion : PERITONEAL CAVITY
Results : POSITIVE
Species : RAT
Route : INTRAVENOUS
Tumor Site: Type of Lesion : PERITONEAL CAVITY; MAMMARY GLAND; INTESTINES
Results : POSITIVE
Reference : [IARC MONOGRAPHS ON THE EVALUATION OF THE
CARCINOGENIC RISK OF CHEMICALS TO HUMANS,
INTERNATIONAL AGENCY FOR RESEARCH ON CANCER,
LYON, FRANCE,p. V10 171 Y76]
Mutagenicity Studies :
Species/Cell Type : E. COLI
Test System : [BRUSICK,DJ, SIMMON,VF, ROSENKRANZ,HS, RAY,
VA AND STAFFORD,RS; AN EVALUATION OF THE
ESCHERICHIA COLI WP2 AND WP2UVRA REVERSE
MUTATION ASSAY; MUTAT. RES. 76:169-190,
1980][GATEHOUSE,D; DETECTION OF MUTAGENIC
DERIVATIVES OF CYCLOPHOSPHAMIDE AND A
VARIETY OF OTHER MUTAGENS IN A 'MICTOTITRE'
FLUCTUATION TEST, WITHOUT MICROSOMAL
ACTIVATION; MUTAT. RES. 53:289-296, 1978]
Strain/Indicator : WP2
Metabolic Activation : NONE
Method : FLUCTUATION (MICROTITRE)
Dose Range : 0-2.0 MG/ML
Results : POSITIVE
Species/Cell Type : E. COLI
Test System : [BRUSICK,DJ, SIMMON,VF, ROSENKRANZ,HS, RAY,
VA AND STAFFORD,RS; AN EVALUATION OF THE
ESCHERICHIA COLI WP2 AND WP2UVRA REVERSE
MUTATION ASSAY; MUTAT. RES. 76:169-190,
1980][GREEN,MHL, MURIEL,WJ AND BRIDGES,BA;
USE OF A SIMPLIFIED FLUCTUATION TEST TO
DETECT LOW LEVELS OF MUTAGENS; MUTAT. RES.
38:33-42, 1976]
Strain/Indicator : WP2
Metabolic Activation : NONE
Method : FLUCTUATION (MICROTITRE)
Dose Range : .0015-.0025 UG/ML
Results : POSITIVE
Species/Cell Type : MOUSE LYMPHOMA
Test System : [CLIVE,D, MCCUEN,R, SPECTOR,JFS, PIPER,C AND
MAVOURNIN,KH; SPECIFIC GENE MUTATIONS IN
L5178Y CELLS IN CULTURE: A REPORT OF THE
U.S. ENVIRONMENTALPROTECTION AGENCY GENE-TOX
PROGRAM; MUTAT. RES. 115:225-251, 1983]
Strain/Indicator : L5178Y (TK+/TK-)
Metabolic Activation : NONE
Method : SUSPENSION/PLATE
Results : POSITIVE
Species/Cell Type : MOUSE LYMPHOMA
Test System : [CLIVE,D, MCCUEN,R, SPECTOR,JFS, PIPER,C AND
MAVOURNIN,KH; SPECIFIC GENE MUTATIONS IN
L5178Y CELLS IN CULTURE: A REPORT OF THE
U.S. ENVIRONMENTALPROTECTION AGENCY GENE-TOX
PROGRAM; MUTAT. RES. 115:225-251, 1983]
Strain/Indicator : L5178Y (TK+/TK-)
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : SUSPENSION/PLATE
Results : POSITIVE
Species/Cell Type : UDS HUMAN CELLS
Test System : [MITCHELL,AD, CASCIANO,DA, MELTZ,ML,
ROBINSON,DE, SAN,RHC, WILLIAMS,GM AND VON
HALLE,ES; UNSCHEDULED DNA SYNTHESIS TESTS: A
REPORT OF THE U.S. ENVIRONMENTALPROTECTION
AGENCY GENE-TOX PROGRAM; MUTAT. RES. 123:363-
410, 1983]
Strain/Indicator : THY INCORP (NON-S-PHASE)
Metabolic Activation : NONE
Method : AUTORADIOGRAPHY
Results : POSITIVE
Species/Cell Type : UDS HUMAN FIBROBLASTS
Test System : [MITCHELL,AD, CASCIANO,DA, MELTZ,ML,
ROBINSON,DE, SAN,RHC, WILLIAMS,GM AND VON
HALLE,ES; UNSCHEDULED DNA SYNTHESIS TESTS: A
REPORT OF THE U.S. ENVIRONMENTALPROTECTION
AGENCY GENE-TOX PROGRAM; MUTAT. RES. 123:363-
410, 1983]
Strain/Indicator : THY INCORP (NON-S-PHASE)
Metabolic Activation : NONE
Method : AUTORADIOGRAPHY
Results : POSITIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA98
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA100
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA1535
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA1538
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA1978
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA1975
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA1975 PKM101
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : POSITIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [FERGUSON,LR, PALMER,BD AND DENNY,WA;
MICROBIAL MUTAGENICITY OF CHLORAMBUCIL, ITS
HALF-MUSTARD AND MITOMYCIN C. A MODIFIED
SCREENING STRATEGY FOR GENETICTOXICOLOGY OF
BIS-ALKYLATING ANTI-TUMOUR DRUGS; ANTI-
CANCER DRUG DES. 3(1): 67-76, 1988]
Strain/Indicator : TA1978 PKM101
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.01-20 UG/PLATE (TEST MATERIAL SOLVENT:
DMSO)
Results : POSITIVE
Species/Cell Type : E. COLI
Test System : [SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O,
YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-
TERM TESTS WITH BACTERIA AND DROSOPHILA FOR
ASSESSMENT OF MUTAGENICITY
OFANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/
2):96-116, 1985]
Strain/Indicator : WP2 (HCR)
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.05-0.2 UG/PLATE (TEST MATERIAL SOLVENT:
WATER)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O,
YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-
TERM TESTS WITH BACTERIA AND DROSOPHILA FOR
ASSESSMENT OF MUTAGENICITY
OFANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/
2):96-116, 1985]
Strain/Indicator : TA100
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.05-0.2 UG/PLATE (TEST MATERIAL SOLVENT:
WATER)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O,
YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-
TERM TESTS WITH BACTERIA AND DROSOPHILA FOR
ASSESSMENT OF MUTAGENICITY
OFANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/
2):96-116, 1985]
Strain/Indicator : TA98
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.05-0.2 UG/PLATE (TEST MATERIAL SOLVENT:
WATER)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O,
YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-
TERM TESTS WITH BACTERIA AND DROSOPHILA FOR
ASSESSMENT OF MUTAGENICITY
OFANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/
2):96-116, 1985]
Strain/Indicator : TA1537
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.05-0.2 UG/PLATE (TEST MATERIAL SOLVENT:
WATER)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [SAKAMOTO,Y, FUJIKAWA,K, NAGAYABU,O,
YAMAMOTO,KS AND SAMEJIMA,K; TRIPLE SHORT-
TERM TESTS WITH BACTERIA AND DROSOPHILA FOR
ASSESSMENT OF MUTAGENICITY
OFANTINEOPLASTICS; TAKEDA KENKYUSHOHO 44(1/
2):96-116, 1985]
Strain/Indicator : TA102
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.05-0.2 UG/PLATE (TEST MATERIAL SOLVENT:
WATER)
Results : POSITIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [WILCOX,P, NAIDOO,A, WEDD,DJ AND GATEHOUSE,
DG; COMPARISON OF SALMONELLA TYPHIMURIUM
TA102 WITH ESCHERICHIA COLI WP2 TESTER
STRAINS; MUTAGENESIS 5(3):285-291, 1990]
Strain/Indicator : TA102
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.005-0.5 UG/PLATE (TEST MATERIAL SOLVENT:
DISTILLED WATER)
Results : POSITIVE
Species/Cell Type : E. COLI
Test System : [WILCOX,P, NAIDOO,A, WEDD,DJ AND GATEHOUSE,
DG; COMPARISON OF SALMONELLA TYPHIMURIUM
TA102 WITH ESCHERICHIA COLI WP2 TESTER
STRAINS; MUTAGENESIS 5(3):285-291, 1990]
Strain/Indicator : WP2 UVRA (PKM101)
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.005-0.5 UG/PLATE (TEST MATERIAL SOLVENT:
DISTILLED WATER)
Results : NEGATIVE
Species/Cell Type : E. COLI
Test System : [WILCOX,P, NAIDOO,A, WEDD,DJ AND GATEHOUSE,
DG; COMPARISON OF SALMONELLA TYPHIMURIUM
TA102 WITH ESCHERICHIA COLI WP2 TESTER
STRAINS; MUTAGENESIS 5(3):285-291, 1990]
Strain/Indicator : WP2 (PKM101)
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.1-10 UG/PLATE (TEST MATERIAL SOLVENT:
DISTILLED WATER)
Results : POSITIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [BLAGOEVA,P, BALANSKI,R, MIRCHEVA,TS AND
SIMEONOVA,M; DIMINISHED GENOTOXICITY OF
MITOMYCIN C AND FARMORUBICIN INCLUDED IN
POLY(BUTYL CYANOACRYLATE) NANOPARTICLES;
MUTAT. RES. 268(1):77-82, 1992]
Strain/Indicator : TA102
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 0.25-2 UG/PLATE
Results : POSITIVE
Species/Cell Type : CHINESE HAMSTER V-79
Test System : [NISHI,Y, HASEGAWA,MM, TAKETOMI,M, OHKAWA,Y
AND INUI,N; COMPARISON OF 6-THIOGUANINE-
RESISTANT MUTATION AND SISTER CHROMATID
EXCHANGES IN CHINESEHAMSTER V-79 CELLS WITH
FORTY CHEMICAL AND PHYSICAL AGENTS; CANCER
RES. 44(8): 3270-3279, 1984]
Strain/Indicator : V-79/6-THIOGUANINE
Metabolic Activation : NONE
Method : FLASK ASSAY
Dose Range : 0.1-1 UG/ML
Results : POSITIVE
Species/Cell Type : CHINESE HAMSTER V-79
Test System : [DAVIES,MJ, PHILLIPS,BJ, ANDERSON,D AND
RUMSBY,PC; MOLECULAR ANALYSIS OF MUTATION AT
THE HPRT LOCUS OF CHINESE HAMSTER V-79 CELLS
INDUCED BY ETHYLMETHANESULFONATE AND
MITOMYCIN C; MUTAT. RES. 291(2):117-124,
1993]
Strain/Indicator : V-79 (HGPRT)/6-THIOGUANINE
Metabolic Activation : NONE
Dose Range : 0.063-0.5 UG/ML
Results : POSITIVE
Species/Cell Type : MOUSE LYMPHOMA
Test System : [OBERLY,TJ, MICHAELIS,KC, REXROAT,MA, BEWSEY,
BJ AND GARRIOTT,ML; A COMPARISON OF THE CHO/
HGPRT+ AND THE L5178Y/TK+/- MUTATION ASSAYS
USING SUSPENSIONTREATMENT AND SOFT AGAR
CLONING: RESULTS FOR 10 CHEMICALS; CELL
BIOL. TOXICOL. 9(3):243-257, 1993]
Strain/Indicator : L5178Y (TK+/TK-)
Metabolic Activation : NONE
Method : SUSPENSION/PLATE
Dose Range : 0.1-0.5 UG/ML
Results : POSITIVE
Species/Cell Type : CHINESE HAMSTER OVARY
Test System : [OBERLY,TJ, MICHAELIS,KC, REXROAT,MA, BEWSEY,
BJ AND GARRIOTT,ML; A COMPARISON OF THE CHO/
HGPRT+ AND THE L5178Y/TK+/- MUTATION ASSAYS
USING SUSPENSIONTREATMENT AND SOFT AGAR
CLONING: RESULTS FOR 10 CHEMICALS; CELL
BIOL. TOXICOL. 9(3):243-257, 1993]
Strain/Indicator : CHO-K1-BH4 (HGPRT)/6-THIOGUANINE
Metabolic Activation : NONE
Method : SUSPENSION/PLATE
Dose Range : 0.03-0.2 UG/ML
Results : POSITIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [HIRAI,O, MIYAMAE,Y, HATTORI,Y, TAKASHIMA,M,
MIYAMOTO,A, ZAIZEN,K AND MINE,Y; MICROBIAL
MUTAGENICITY AND IN VITRO CHROMOSOME
ABERRATION INDUCTION BY FK973,A NEW
ANTITUMOR AGENT; MUTAT. RES. 324(1-2):43-50,
1994]
Strain/Indicator : TA102
Metabolic Activation : NONE
Method : PREINCUBATION
Dose Range : 0.001-10 UG/PLATE (TEST MATERIAL SOLVENT:
SALINE)
Results : POSITIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [HIRAI,O, MIYAMAE,Y, HATTORI,Y, TAKASHIMA,M,
MIYAMOTO,A, ZAIZEN,K AND MINE,Y; MICROBIAL
MUTAGENICITY AND IN VITRO CHROMOSOME
ABERRATION INDUCTION BY FK973,A NEW
ANTITUMOR AGENT; MUTAT. RES. 324(1-2):43-50,
1994]
Strain/Indicator : TA102
Metabolic Activation : RAT, LIVER, S-9, PHENOBARBITAL AND 5,6-
BENZOFLAVONE
Method : PREINCUBATION
Dose Range : 0.001-10 UG/PLATE (TEST MATERIAL SOLVENT:
SALINE)
Results : POSITIVE
Species/Cell Type : UDS RAT HEPATOCYTES
Test System : [DENG,D, MULLER,K, KASPER,P AND MULLER,L;
MODULATION OF MUTAGENIC DRUG-INDUCED
UNSCHEDULED DNA SYNTHESIS (UDS) IN PRIMARY
RAT HEPATOCYTES BY DIALLYLTRISULFIDE;
ZHONGHUA ZHONGLIU ZAZHI 15(6):423-426, 1993]
Strain/Indicator : THY INCORP
Metabolic Activation : NONE
Method : AUTORADIOGRAPHY
Dose Range : 1-10 UMOL/L
Results : POSITIVE
Species/Cell Type : CHINESE HAMSTER V-79
Test System : [DAVIES,MJ, PHILLIPS,BJ AND RUMSBY,PC;
MOLECULAR ANALYSIS OF CHEMICALLY-INDUCED
MUTATIONS IN MAMMALIAN CELL ASSAYS; TOXICOL.
IN VITRO 9(4):513-518, 1995]
Strain/Indicator : V-79 (HPRT)/6-THIOGUANINE
Metabolic Activation : NONE
Method : FLUCTUATION TEST
Dose Range : 0-0.5 UG/ML
Results : NEGATIVE
Species/Cell Type : MOUSE LYMPHOMA
Test System : [DAVIES,MJ, PHILLIPS,BJ AND RUMSBY,PC;
MOLECULAR ANALYSIS OF CHEMICALLY-INDUCED
MUTATIONS IN MAMMALIAN CELL ASSAYS; TOXICOL.
IN VITRO 9(4):513-518, 1995]
Strain/Indicator : L5178Y (TK+/TK-)
Metabolic Activation : NONE
Method : FLUCTUATION TEST
Dose Range : 0-0.25 UG/ML
Results : POSITIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1535
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1535
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1537
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1537
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA98
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA98
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA100
Metabolic Activation : NONE
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA100
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : STANDARD PLATE
Dose Range : 1-300 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA10O
Metabolic Activation : NONE
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA100
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1535
Metabolic Activation : NONE
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1535
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1537
Metabolic Activation : NONE
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA1537
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA98
Metabolic Activation : NONE
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Species/Cell Type : AMES SALMONELLA TYPHIMURIUM
Test System : [DIEHL,M AND FORT,F; SPIRAL SALMONELLA
ASSAY: VALIDATION AGAINST THE STANDARD POUR-
PLATE ASSAY; ENVIRON. MOL. MUTAGEN.
27(3):227-236, 1996]
Strain/Indicator : TA98
Metabolic Activation : RAT, LIVER, S-9, AROCLOR 1254
Method : SPIRAL ASSAY
Dose Range : 2-499 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
Results : NEGATIVE
Tumor Inhibitor Studies :
Species : RAT
Number of Animals Tested : (20,20)/(10,10)
Strain/Sex : WISTAR/MALE
Route [Inhibitor] : INTRAVESICAL
Dose [Inhibitor] : 0.5 ML (2000 UG/ML) INSTILLED
TRANSURETHRALLY 2/WK FOR 2 WK POST
CARCINOGEN DOSE
Study Duration : 20 Week/s
Carcinogen : N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE ; 3817-
11-6
Route [Carcinogen] : ORAL
Dose [Carcinogen] : 0.05% IN DRINKING WATER FOR 12 WK
Promoter : NONE USED
Target Tissue: Type of Lesion: BLADDER: PAPILLOMA
Endpoint [Incidence] : 6/20 (30%), 2/10 (20%), 33%, NOT CALCULATED
Endpoint [Multiplicity] : 0.3, 0.2, 33%, NOT CALCULATED
Species : RAT
Number of Animals Tested : (20,20)/(10,10)
Strain/Sex : WISTAR/MALE
Route [Inhibitor] : INTRAVESICAL
Dose [Inhibitor] : 0.5 ML (2000 UG/ML) INSTILLED
TRANSURETHRALLY 2/WK FOR 2 WK POST
CARCINOGEN DOSE
Study Duration : 20 Week/s
Carcinogen : N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE ; 3817-
11-6
Route [Carcinogen] : ORAL
Dose [Carcinogen] : 0.05% IN DRINKING WATER FOR 12 WK
Promoter : NONE USED
Target Tissue: Type of Lesion: BLADDER: CARCINOMA
Endpoint [Incidence] : 14/20 (70%), 8/10 (80%), -14%, NOT CALCULATED
Endpoint [Multiplicity] : 0.7, 0.8, -14%, NOT CALCULATED
Species : RAT
Number of Animals Tested : (20,20)/(10,10)
Strain/Sex : WISTAR/MALE
Route [Inhibitor] : INTRAVESICAL
Dose [Inhibitor] : 2000 UG/ML INSTILLED CONTINUOUSLY FOR 2 WK
POST CARCINOGEN DOSE
Study Duration : 12 Week/s
Carcinogen : N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE ; 3817-
11-6
Route [Carcinogen] : ORAL
Dose [Carcinogen] : 0.05% IN DRINKING WATER FOR 12 WK
Promoter : NONE USED
Target Tissue: Type of Lesion: BLADDER: CARCINOMA
Endpoint [Incidence] : 14/20 (70%), 2/10 (20%), 71%, NOT CALCULATED
Endpoint [Multiplicity] : 0.7, 0.2, 71%, P<0.02
Species : RAT
Number of Animals Tested : (20,20)/(10,10)
Strain/Sex : WISTAR/MALE
Route [Inhibitor] : INTRAVESICAL
Dose [Inhibitor] : 2000 UG/ML INSTILLED CONTINUOUSLY FOR 2 WK
POST CARCINOGEN DOSE
Study Duration : 12 Week/s
Carcinogen : N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE ; 3817-
11-6
Route [Carcinogen] : ORAL
Dose [Carcinogen] : 0.05% IN DRINKING WATER FOR 12 WK
Promoter : NONE USED
Target Tissue: Type of Lesion: BLADDER: PAPILLOMA
Endpoint [Incidence] : 6/20 (30%), 2/10 (20%), 33%, NOT CALCULATED
Endpoint [Multiplicity] : 0.3, 0.2, 33%, NOT CALCULATED
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