BiblioLine Sample Record
DATABASE FILE: GENE-TOX
CAS REGISTRY NUMBER: 50-76-0
CHEMICAL NAME: ACTINOMYCIN D
CHEMICAL CLASSIFICATION CATEGORY: Antibiotics, mycotoxins;   Aromatic amines, aliphatic amines, amides and sulfonamides;   Dioxins, xanthenes, thioxanthenes, phenothiazines;   Lactones, organic peroxides
TAXONOMIC NAME & ASSAY: Lower eukaryotes - gene mutation;   Plants - gene mutation;   Insects - gene mutation;   In vitro mammalian - gene mutation;   Plants - chromosome effects;   Insects - chromosome effects;   In vitro mammalian - chromosome effects;   In vivo mammalian somatic cells - chromosome effects;   Prokaryotes - other genotoxic effects;   In vitro mammalian, SCE - other genotoxic effects;   In vivo mammalian, sperm morphology - other genotoxic effects;   In vitro mammalian - cell transformation
MUTAGENECITY STUDIES: 
Gene-Tox Evaluation B (Post-1980)
 
    Species/Cell Type: Chinese hamster ovary (CHO) cells
    Assay Type       : Forward gene mutation at the HPRT locus
    Assay Code       : CHO+
    Results          : Positive
    Reference        : EMICBACK/71517; MUTAT RES 196:17-36,1988
                       EMICBACK/45725; MUTAT RES 94:449-466,1982
 
    Species/Cell Type: Nonhuman
    Assay Type       : Sister-chromatid exchange (SCE) in vivo
    Assay Code       : SC3+
    Results          : Positive
    Reference        : EMIC/91392; Mutat Res 1993 Sep;297(2):101-80
 
    Species/Cell Type: Human lymphocytes
    Assay Type       : Sister-chromatid exchange (SCE) in vivo
    Assay Code       : SCY+
    Results          : Positive
    Reference        : EMIC/91392; Mutat Res 1993 Sep;297(2):101-80
                       EMICBACK/31225; MUTAT RES 59:295-300,1979
 
Gene-Tox Evaluation A (Pre-1980)
 
    Species/Cell Type: Mouse (C3H/10T1/2) cells
    Assay Type       : Cell transformation
    Assay Code       : CTH+
    Results          : Positive
    Reference        : EMICBACK/50076; MUTAT RES 114:283-385,1983
 
    Species/Cell Type: Nonhuman
    Assay Type       : Chromosome aberrations in vitro
    Assay Code       : CY&+
    Results          : Positive
    Reference        : EMICBACK/41729; MUTAT RES 87:143-188,1981
 
    Species/Cell Type: Human cell culture
    Assay Type       : Chromosome aberrations in vitro
    Assay Code       : CYZ+D
    Results          : Positive
    Dose Response    : With dose response
    Reference        : EMICBACK/41729; MUTAT RES 87:143-188,1981
 
    Species/Cell Type: Mammalian polychromatic erythrocytes
    Assay Type       : Micronucleus test, chromosome aberrations
    Assay Code       : MNTT
    Results          : No conclusion
    Reference        : EMICBACK/50890; MUTAT RES 123:61-118,1983
 
    Species/Cell Type: Neurospora crassa
    Assay Type       : Forward gene mutation
    Assay Code       : NEF+
    Results          : Positive
    Reference        : EMICBACK/52327; MUTAT RES 133:87-134,1984
 
    Species/Cell Type: Glycine max (soybean)
    Assay Type       : Gene mutation
    Assay Code       : GLM+
    Results          : Positive
    Reference        : EMICBACK/48097; MUTAT RES 99:339-347,1982
 
    Species/Cell Type: Allium cepa
    Assay Type       : Chromosome aberrations
    Assay Code       : ALC+
    Results          : Positive
    Reference        : EMICBACK/48093; MUTAT RES 99:273-291,1982
 
    Species/Cell Type: Escherichia coli polA (W3119 vs P3478)
    Assay Type       : Rec-assay, DNA effects (bacterial DNA repair)
    Assay Code       : RE1T
    Results          : No conclusion
    Reference        : EMICBACK/45048; MUTAT RES 87:211-297,1981
 
    Species/Cell Type: Nonhuman
    Assay Type       : Sister-chromatid exchange (SCE) in vitro
    Assay Code       : SC2+
    Results          : Positive
    Reference        : EMICBACK/41613; MUTAT RES 87:17-62,1981
 
    Species/Cell Type: Mouse
    Sex              : Male
    Assay Type       : Sperm morphology
    Assay Code       : SPI+
    Results          : Positive
    Reference        : EMICBACK/50126; MUTAT RES 115:1-72,1983
 
    Species/Cell Type: Drosophila melanogaster
    Assay Type       : Sex-linked recessive lethal gene mutation
    Assay Code       : SRLT
    Results          : No conclusion
    Reference        : EMICBACK/50912; MUTAT RES 123:183-279,1983
 
    Species/Cell Type: Chinese hamster lung (V79) cells
    Assay Type       : Forward gene mutation at the HPRT or ouabain locus
    Assay Code       : V79-
    Results          : Negative
    Reference        : EMICBACK/41728; MUTAT RES 87:81-142,1981
 
    Species/Cell Type: Saccharomyces cerevisiae
    Assay Type       : Forward gene mutation
    Assay Code       : YEFT
    Results          : No conclusion
    Reference        : EMICBACK/52546; MUTAT RES 133:199-244,1984
 
    Species/Cell Type: Drosophila melanogaster
    Assay Type       : Aneuploidy, sex chromosome gain, chromosome
                       aberrations
    Assay Code       : DAG+F
    Results          : Positive
    Reference        : EMICBACK/52867; MUTAT RES 134:61-88,1984
 
    Species/Cell Type: Drosophila melanogaster
    Assay Type       : Aneuploidy, whole sex chromosome loss, chromosome
                       aberrations
    Assay Code       : DAC+F
    Results          : Positive
    Reference        : EMICBACK/52867; MUTAT RES 134:61-88,1984
 
    Species/Cell Type: Nonhuman
    Assay Type       : In vivo carcinogenicity studies
    Assay Code       : CCG+L
    Results          : Positive
    Reference        : EMICBACK/67174; MUTAT RES 185:1-195,1987
PUBLICATION YEAR: 1998
CIS RECORD ID.: GEN-00040

END OF RECORD

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