| DATABASE FILE: |
NIOSHTIC SUBSET [HAZMAT Bibliographic
References] |
| CAS REGISTRY NUMBER: |
84-74-2; 85-68-7 |
| TITLE: |
Comparative Developmental Toxicity of n-Butyl
Benzyl Phthalate and Di-n-butyl Phthalate in Rats. |
| AUTHOR: |
Ema, M; R. Kurosaka;
H. Amano; Y. Ogawa |
| SOURCE/JOURNAL: |
Archives of Environmental Contamination and
Toxicology; Vol. 28, No. 2, pages 223-228, 30 references; 1995 |
| PUBLICATION YEAR: |
1995 |
| INDEX TERMS: |
|
Plasticizers;
Teratogenesis; Prenatal exposure; Phthalates;
Embryotoxicity; Laboratory animals; In vivo study |
| ABSTRACT: |
|
This study compared the
developmental toxicity of n-butyl-benzyl-phthalate (85687) (BBP) and di-n-butyl-phthalate
(84742) (DBP) in female Wistar-rats, and assessed the role of the metabolite in
developmental toxicity. Pregnant rats were dosed with 0.75, 1.0, or 1.25 gram/kilogram
(g/kg) BDP or BBP by gastric intubation on days seven through nine, ten through 12, and 13
through 15 of pregnancy. Each treatment caused a significant increase in the incidence of
postimplantation loss at all dose levels. Treatment with BBP and DBP at doses above
0.75g/kg on days seven through nine or 13 through 15 significantly increased the incidence
of fetuses with malformations. No increase was noted in the incidence of malformed fetuses
after DBP or BBP treatment on days 10 through 12. Postimplantation loss and malformed
fetuses increased in incidence rate as the dose levels of the two chemicals were
increased. The vertebral column and ribs were usually deformed after treatment with the
chemicals on days seven through nine. A predominant observation of cleft palate and fusion
was noted following treatment on days 13 through 15. The authors suggest that the two
chemicals act in similar ways, possibly through a common metabolite. |
| PUB. TYPE: |
Journal Article |
| CIS RECORD ID.: |
CN-0001529 |
|
This record is provided from the NIOSHTIC
database of the National Institute for Occupational Safety and Health of the U.S.
Department of Health and Human Services, United States. |