| DATABASE FILE: RTECS [Toxicity,
Carcinogenicity, Tumorigenicity, Mutagenicity, Teratogenicity] |
| CAS REGISTRY NUMBER: 50-00-0 |
| OTHER CAS REGISTRY NUMBER: 8005-38-7;
8006-07-3; 8013-13-6; 112068-71-0 |
| RTECS NUMBER: LP8925000 |
| CHEMICAL NAME: Formaldehyde |
| SYNONYMS: |
Aldehyde formique (French)
Aldehyd mravenci (Czech)
Aldeide formica (Italian)
BFV
Fannoform
Formaldehyde (ACGIH:OSHA)
Formaldehyd (Czech, Polish)
Formaldehyde, gas
Formalin
Formalin 40
Formalina (Italian)
Formaline (German)
Formalin-loesungen (German)
Formalith
Formic aldehyde
Formol
FYDE
Lysoform
Methaldehyde
Methanal
Methyl aldehyde
Methylene oxide
Morbicid
NCI-C02799
Oplossingen (Dutch)
Oxomethane
Oxymethylene
Paraform
RCRA waste number U122
Superlysoform
|
| MOLECULAR FORMULA: C-H2-O |
| MOLECULAR WEIGHT: 30.03 |
| WISWESSER NOTATION: VHH |
| SUBSTANCE CATEGORY: Agricultural
Chemical [A]; Tumorigen [C]; Mutagen [M]; Reproductive
Effector [T]; Primary Irritant [S] |
| IRRITATION DATA: |
Route of Administration : skn - Skin
Species Tested : hmn - Human
Dosage : 150 ug/3D-I
Irritant Effect : MLD - Mild
Source : 85DKA8 - "Cutaneous Toxicity, Proceedings of the
3rd Conference, 1976," Drill, V.A., and P.
Lazar, eds., New York, Academic Press, Inc.
1977 p.127 1977
Route of Administration : eye - Eyes
Species Tested : hmn - Human
Dosage : 4 ppm/5M
Source : IAPWAR - International Journal of Air and Water
Pollution 4:79, 1961
Route of Administration : eye - Eyes
Species Tested : hmn - Human
Dosage : 1 ppm/6M nse
Irritant Effect : MLD - Mild
Source : AIHAAP - American Industrial Hygiene Association
Journal 44:463, 1983
Route of Administration : skn - Skin
Species Tested : rbt - Rabbit, adult
Dosage : 2 mg/24H
Irritant Effect : SEV - Severe
Source : 85JCAE - "Prehled Prumyslove Toxikologie;
Organicke Latky," Marhold, J., Prague,
Czechoslovakia, Avicenum, 1986 p.264 1986
Route of Administration : skn - Skin
Species Tested : rbt - Rabbit, adult
Dosage : 540 mg open
Irritant Effect : MLD - Mild
Source : UCDS** - Union Carbide Data Sheet. (Union
Carbide Corp., 39 Old Ridgebury Rd., Danbury,
CT 06817) 4/21/1967
Route of Administration : skn - Skin
Species Tested : rbt - Rabbit, adult
Dosage : 50 mg/24H
Irritant Effect : MOD - Moderate
Source : TXAPA9 - Toxicology and Applied Pharmacology
21:369, 1972
Route of Administration : eye - Eyes
Species Tested : rbt - Rabbit, adult
Dosage : 750 ug/24H
Irritant Effect : SEV - Severe
Source : 85JCAE - "Prehled Prumyslove Toxikologie;
Organicke Latky," Marhold, J., Prague,
Czechoslovakia, Avicenum, 1986 p.264 1986
Route of Administration : eye - Eyes
Species Tested : rbt - Rabbit, adult
Dosage : 750 ug
Irritant Effect : SEV - Severe
Source : AJOPAA - American Journal of Ophthalmology
29:1363, 1946
Route of Administration : eye - Eyes
Species Tested : rbt - Rabbit, adult
Dosage : 10 mg
Irritant Effect : SEV - Severe
Source : TXAPA9 - Toxicology and Applied Pharmacology
55:501, 1980
|
| MUTATION DATA: |
Mutation Test System : mmo - Mutation in Microorganisms
Organism : sat - Salmonella typhimurium
Dose Data : 100 umol/L (+/-S9)
Source : MUTAEX - Mutagenesis 1:427, 1986
Mutation Test System : oms - Other Mutation Systems
Organism : sat - Salmonella typhimurium
Dose Data : 19 mg/L
Source : MUREAV - Mutation Research 192:239, 1987
Mutation Test System : mmo - Mutation in Microorganisms
Organism : esc - Escherichia coli
Dose Data : 100 ppm/3H (-S9)
Source : AMNTA4 - American Naturalist 85:119, 1951
Mutation Test System : oms - Other Mutation Systems
Organism : esc - Escherichia coli
Dose Data : 300 umol/L
Source : MUREAV - Mutation Research 203:81, 1988
Mutation Test System : dnr - DNA Repair
Organism : esc - Escherichia coli
Dose Data : 1950 ug/L
Source : CRNGDP - Carcinogenesis (London) 2:189, 1981
Mutation Test System : dna - DNA Adduct
Organism : esc - Escherichia coli
Dose Data : 5 ppm
Source : MUREAV - Mutation Research 89:95, 1981
Mutation Test System : dni - DNA Inhibition
Organism : esc - Escherichia coli
Dose Data : 5 mmol/L
Source : MUREAV - Mutation Research 156:153, 1985
Mutation Test System : pic - Phage Inhibition capacity
Organism : esc - Escherichia coli
Dose Data : 25 ug/well
Source : MUREAV - Mutation Research 260:349, 1991
Mutation Test System : mmo - Mutation in Microorganisms
Organism : srm - Serratia marcescens
Dose Data : 5 gm/L (-S9)
Source : ATXKA8 - Archiv fuer Toxikologie 28:93, 1971
Mutation Test System : mmo - Mutation in Microorganisms
Organism : omi - Other microorganisms
Dose Data : 1 pph/5M-C (-S9)
Source : MMAPAP - Mycopathologia et Mycologia Applicata
49:205, 1973
Mutation Test System : mmo - Mutation in Microorganisms
Organism : omi - Other microorganisms
Dose Data : 10 ppm (-S9)
Source : POASAD - Proceedings of the Oklahoma Academy of
Science 34:114, 1953
Mutation Test System : mmo - Mutation in Microorganisms
Organism : omi - Other microorganisms
Dose Data : 200 ppm (-S9)
Source : APMBAY - Applied Microbiology 6:45, 1958
Mutation Test System : mmo - Mutation in Microorganisms
Organism : omi - Other microorganisms
Dose Data : 1000 ppm (-S9)
Source : JOBAAY - Journal of Bacteriology 63:1, 1952
Mutation Test System : mmo - Mutation in Microorganisms
Organism : omi - Other microorganisms
Dose Data : 250 ppm (-S9)
Source : SOGEBZ - Soviet Genetics. English translation of
GNKAA5 8:412, 1972
Mutation Test System : mmo - Mutation in Microorganisms
Organism : omi - Other microorganisms
Dose Data : 1 pph/15M (-S9)
Source : MUREAV - Mutation Research 7:19, 1969
Mutation Test System : mmo - Mutation in Microorganisms
Organism : omi - Other microorganisms
Dose Data : 200 umol/L (-S9)
Source : MUREAV - Mutation Research 62:239, 1979
Mutation Test System : slt - Specific Locus Test
Organism : dmg - Drosophila melanogaster
Tissue Tested : orl - Oral
Dose Data : 12500 umol/L
Source : MUREAV - Mutation Research 182:243, 1987
Mutation Test System : sln - Sex Chromosome Loss and Nondisjunction
Organism : dmg - Drosophila melanogaster
Dose Data : 10 pph/3H-C
Source : AMNTA4 - American Naturalist 90:377, 1956
Mutation Test System : sln - Sex Chromosome Loss and Nondisjunction
Organism : dmg - Drosophila melanogaster
Tissue Tested : ihl - Inhalation
Dose Data : 7 pph/24H
Source : THAGA6 - Theoretical & Applied Genetics 39:330,
1969
Mutation Test System : sln - Sex Chromosome Loss and Nondisjunction
Organism : dmg - Drosophila melanogaster
Tissue Tested : orl - Oral
Dose Data : 250 ppm
Source : THAGA6 - Theoretical & Applied Genetics 39:330,
1969
Mutation Test System : sln - Sex Chromosome Loss and Nondisjunction
Organism : dmg - Drosophila melanogaster
Tissue Tested : par - Parenteral
Dose Data : 2000 ppm
Source : ENMUDM - Environmental Mutagenesis 7:677, 1985
Mutation Test System : dlt - Dominant Lethal test
Organism : dmg - Drosophila melanogaster
Tissue Tested : orl - Oral
Dose Data : 1300 ppm
Source : MGGEAE - Molecular and General Genetics 106:286,
1970
Mutation Test System : mmo - Mutation in Microorganisms
Organism : nsc - Neurospora crassa
Dose Data : 10 mmol/plate (-S9)
Source : CSHSAZ - Cold Spring Harbor Symposia on
Quantitative Biology 16:245, 1952
Mutation Test System : mrc - Gene Conversion and Mitotic Recombination
Organism : smc - Saccharomyces cerevisiae
Dose Data : 24 mmol/L
Source : MUREAV - Mutation Research 33:179, 1975
Mutation Test System : sln - Sex Chromosome Loss and Nondisjunction
Organism : asn - Aspergillus nidulans
Dose Data : 20 mg/L
Source : EVHPAZ - EHP, Environmental Health Perspectives
31:81, 1979
Mutation Test System : slt - Specific Locus Test
Organism : nml - Non-mammalian species
Dose Data : 700 ppm
Source : MUREAV - Mutation Research 80:273, 1981
Mutation Test System : oms - Other Mutation Systems
Organism : nml - Non-mammalian species
Tissue Tested : oth - Other
Dose Data : 40 mmol/L
Source : CAANAT - Comptes Rendus de l'Association des
Anatomistes 56:712, 1972
Mutation Test System : oms - Other Mutation Systems
Organism : nml - Non-mammalian species
Tissue Tested : oth - Other
Dose Data : 25 mmol/L
Source : ECREAL - Experimental Cell Research 95:233, 1975
Mutation Test System : cyt - Cytogenetic Analysis
Organism : nml - Non-mammalian species
Tissue Tested : oth - Other
Dose Data : 40 mmol/L
Source : CAANAT - Comptes Rendus de l'Association des
Anatomistes 56:712, 1972
Mutation Test System : cyt - Cytogenetic Analysis
Organism : grh - Grasshopper
Tissue Tested : oth - Other
Dose Data : 750 umol/L
Source : ENMUDM - Environmental Mutagenesis 8:401, 1986
Mutation Test System : sln - Sex Chromosome Loss and Nondisjunction
Organism : nml - Non-mammalian species
Tissue Tested : mul - Multiple
Dose Data : 700 ppm
Source : MUREAV - Mutation Research 201:137, 1988
Mutation Test System : dnd - DNA Damage
Organism : hmn - Human
Tissue Tested : lym - Lymphocyte
Dose Data : 10 umol/L
Source : CRNGDP - Carcinogenesis (London) 17:121, 1996
Mutation Test System : dnd - DNA Damage
Organism : hmn - Human
Tissue Tested : fbr - Fibroblast
Dose Data : 100 umol/L
Source : ENMUDM - Environmental Mutagenesis 7:267, 1985
Mutation Test System : dnd - DNA Damage
Organism : hmn - Human
Tissue Tested : lng - Lung
Dose Data : 100 umol/L
Source : SCIEAS - Science 220:216, 1983
Mutation Test System : dnd - DNA Damage
Organism : hmn - Human
Tissue Tested : oth - Other
Dose Data : 100 umol/L
Source : CNREA8 - Cancer Research 45:2522, 1985
Mutation Test System : dns - Unscheduled DNA Synthesis
Organism : hmn - Human
Dose Data : 10 nmol/L
Source : CNREA8 - Cancer Research 38:2621, 1978
Mutation Test System : dni - DNA Inhibition
Organism : hmn - Human
Tissue Tested : oth - Other
Dose Data : 210 umol/L
Source : CNREA8 - Cancer Research 45:2522, 1985
Mutation Test System : oms - Other Mutation Systems
Organism : hmn - Human
Tissue Tested : oth - Other
Dose Data : 210 umol/L
Source : CNREA8 - Cancer Research 45:2522, 1985
Mutation Test System : dni - DNA Inhibition
Organism : hmn - Human
Dose Data : 400 umol/L
Source : CRNGDP - Carcinogenesis (London) 13:2389, 1992
Mutation Test System : oms - Other Mutation Systems
Organism : hmn - Human
Tissue Tested : lym - Lymphocyte
Dose Data : 10 mg/L
Source : TSITAQ - Tsitologiya. Cytology 24:1056, 1982
Mutation Test System : cyt - Cytogenetic Analysis
Organism : hmn - Human
Tissue Tested : lym - Lymphocyte
Dose Data : 10 mg/L
Source : TSITAQ - Tsitologiya. Cytology 24:1056, 1982
Mutation Test System : cyt - Cytogenetic Analysis
Organism : hmn - Human
Tissue Tested : fbr - Fibroblast
Dose Data : 2 mmol/L
Source : MUREAV - Mutation Research 119:309, 1983
Mutation Test System : sce - Sister Chromatid Exchange
Organism : hmn - Human
Tissue Tested : lym - Lymphocyte
Dose Data : 125 umol/L
Source : MUTAEX - Mutagenesis 1:427, 1986
Mutation Test System : msc - Mutation in Mammalian Somatic cells
Organism : hmn - Human
Tissue Tested : lym - Lymphocyte
Dose Data : 130 umol/L
Source : 50RXAH - "Formaldehyde: Toxicology, Epidemiology,
Mechanisms, Papers of a Meeting, 2nd, 1982," Clary,
J.J., et al., eds., New York, Marcel Dekker, 1983
2,173,1983
Mutation Test System : mnt - Micronucleus Test
Organism : rat - Rat
Tissue Tested : orl - Oral
Dose Data : 200 mg/kg/30H
Source : MUTAEX - Mutagenesis 4:327, 1989
Mutation Test System : mtr - Morphological Transformation
Organism : rat - Rat
Tissue Tested : kdy - Kidney
Dose Data : 100 umol/L/3H
Source : EJCODS - European Journal of Cancer and Clinical
Oncology 22:671, 1986
Mutation Test System : dnd - DNA Damage
Organism : rat - Rat
Tissue Tested : lvr - Liver
Dose Data : 1 mmol/L
Source : CRNGDP - Carcinogenesis (London) 15:991, 1994
Mutation Test System : dnd - DNA Damage
Organism : rat - Rat
Tissue Tested : ihl - Inhalation
Dose Data : 35 ug/m3/8W-I
Source : PRKHDK - Problemi na Khigienata. Problems in
Hygiene 4:101, 1979
Mutation Test System : dnd - DNA Damage
Organism : rat - Rat
Tissue Tested : orl - Oral
Dose Data : 10 umol/kg
Source : ENMUDM - Environmental Mutagenesis 4:317, 1982
Mutation Test System : dnd - DNA Damage
Organism : rat - Rat
Tissue Tested : oth - Other
Dose Data : 500 umol/L
Source : ENMUDM - Environmental Mutagenesis 8(Suppl 6):11,
1986
Mutation Test System : dnd - DNA Damage
Organism : rat - Rat
Tissue Tested : oth - Other
Dose Data : 200 umol/L
Source : TXCYAC - Toxicology 51:309, 1988
Mutation Test System : dns - Unscheduled DNA Synthesis
Organism : rat - Rat
Tissue Tested : oth - Other
Dose Data : 50 umol/L
Source : ENMUDM - Environmental Mutagenesis 8(Suppl 6):11,
1986
Mutation Test System : dns - Unscheduled DNA Synthesis
Organism : rat - Rat
Tissue Tested : orl - Oral
Dose Data : 55 mg/kg
Source : JJCREP - Japanese Journal of Cancer Research.
(Elsevier Science Pub. BV, POB 211, 1000 AE
Amsterdam, Netherlands) V.76- 1985- 79:917, 1988
Mutation Test System : dns - Unscheduled DNA Synthesis
Organism : rat - Rat
Tissue Tested : lvr - Liver
Dose Data : 400 mmol/L
Source : MUREAV - Mutation Research 221:263, 1989
Mutation Test System : dni - DNA Inhibition
Organism : rat - Rat
Tissue Tested : oth - Other
Dose Data : 100 umol/L
Source : ENMUDM - Environmental Mutagenesis 8(Suppl 6):11,
1986
Mutation Test System : oms - Other Mutation Systems
Organism : rat - Rat
Tissue Tested : oth - Other
Dose Data : 100 umol/L
Source : ENMUDM - Environmental Mutagenesis 8(Suppl 6):11,
1986
Mutation Test System : cyt - Cytogenetic Analysis
Organism : rat - Rat
Tissue Tested : ihl - Inhalation
Dose Data : 500 ug/m3/17W-C
Source : GISAAA - Gigiena i Sanitariya. For English
translation, see HYSAAV 53(5):75, 1988
Mutation Test System : cyt - Cytogenetic Analysis
Organism : rat - Rat
Tissue Tested : ihl - Inhalation
Dose Data : 15 ppm/5D-I
Source : ENMUDM - Environmental Mutagenesis 7(Suppl 3):53,
1985
Mutation Test System : dlt - Dominant Lethal test
Organism : rat - Rat
Tissue Tested : ipr - Intraperitoneal
Dose Data : 625 ug/kg/5D-C
Source : MUREAV - Mutation Research 389:141, 1997
Mutation Test System : spm - Sperm Morphology
Organism : rat - Rat
Tissue Tested : orl - Oral
Dose Data : 200 mg/kg
Source : ARTODN - Archives of Toxicology 53:71, 1983
Mutation Test System : spm - Sperm Morphology
Organism : rat - Rat
Tissue Tested : ipr - Intraperitoneal
Dose Data : 625 ug/kg/5D-C
Source : MUREAV - Mutation Research 389:141, 1997
Mutation Test System : mmo - Mutation in Microorganisms
Organism : mus - Mouse
Tissue Tested : lym - Lymphocyte
Dose Data : 25 mg/L (+S9)
Source : FCTOD7 - Food and Chemical Toxicology 23:115, 1985
Mutation Test System : mtr - Morphological Transformation
Organism : mus - Mouse
Tissue Tested : emb - Embryo
Dose Data : 1 mg/L
Source : ENMUDM - Environmental Mutagenesis 4:357, 1982
Mutation Test System : dnd - DNA Damage
Organism : mus - Mouse
Tissue Tested : lvr - Liver
Dose Data : 250 umol/L
Source : CRNGDP - Carcinogenesis (London) 15:991, 1994
Mutation Test System : dnd - DNA Damage
Organism : mus - Mouse
Tissue Tested : leu - Leukocyte
Dose Data : 125 umol/L
Source : JJIND8 - JNCI, Journal of the National Cancer
Institute 67:217, 1981
Mutation Test System : cyt - Cytogenetic Analysis
Organism : mus - Mouse
Tissue Tested : orl - Oral
Dose Data : 100 mg/kg
Source : ENMUDM - Environmental Mutagenesis 4:317, 1982
Mutation Test System : cyt - Cytogenetic Analysis
Organism : mus - Mouse
Tissue Tested : ipr - Intraperitoneal
Dose Data : 15 mg/kg
Source : ENMUDM - Environmental Mutagenesis 5:381, 1983
Mutation Test System : msc - Mutation in Mammalian Somatic cells
Organism : mus - Mouse
Tissue Tested : lym - Lymphocyte
Dose Data : 74 mg/L
Source : FCTOD7 - Food and Chemical Toxicology 23:115, 1985
Mutation Test System : hma - Host-Mediated Assay
Organism : mus - Mouse
Dose Data : 10 mg/kg
Source : MUREAV - Mutation Research 272:161, 1992
Mutation Test System : mtr - Morphological Transformation
Organism : ham - Hamster
Tissue Tested : emb - Embryo
Dose Data : 125 ug/L
Source : MUREAV - Mutation Research 356:85, 1996
Mutation Test System : mtr - Morphological Transformation
Organism : ham - Hamster
Tissue Tested : kdy - Kidney
Dose Data : 4 mg/L
Source : CRNGDP - Carcinogenesis (London) 4:457, 1983
Mutation Test System : dnd - DNA Damage
Organism : ham - Hamster
Tissue Tested : ovr - Ovary
Dose Data : 1 mmol/L
Source : MUREAV - Mutation Research 367:143, 1996
Mutation Test System : pic - Phage Inhibition capacity
Organism : ham - Hamster
Tissue Tested : emb - Embryo
Dose Data : 3 ul/L
Source : ENMUDM - Environmental Mutagenesis 6:474, 1984
Mutation Test System : cyt - Cytogenetic Analysis
Organism : ham - Hamster
Tissue Tested : lng - Lung
Dose Data : 18 mg/L
Source : GMCRDC - Gann Monograph on Cancer Research 27:95,
1981
Mutation Test System : cyt - Cytogenetic Analysis
Organism : ham - Hamster
Tissue Tested : ovr - Ovary
Dose Data : 200 ug/L
Source : ENMUDM - Environmental Mutagenesis 7:1, 1985
Mutation Test System : sce - Sister Chromatid Exchange
Organism : ham - Hamster
Tissue Tested : lng - Lung
Dose Data : 67 umol/L
Source : ARTODN - Archives of Toxicology 58:10, 1985
Mutation Test System : sce - Sister Chromatid Exchange
Organism : ham - Hamster
Tissue Tested : ovr - Ovary
Dose Data : 110 ug/L
Source : ENMUDM - Environmental Mutagenesis 7:1, 1985
Mutation Test System : msc - Mutation in Mammalian Somatic cells
Organism : ham - Hamster
Tissue Tested : ovr - Ovary
Dose Data : 1 mmol/L
Source : MUREAV - Mutation Research 367:143, 1996
Mutation Test System : dnd - DNA Damage
Organism : ckn - Chicken, adult(male or female)
Tissue Tested : leu - Leukocyte
Dose Data : 500 ppm
Source : CELLB5 - Cell (Cambridge, Mass.) 5:45, 1975
Mutation Test System : spm - Sperm Morphology
Organism : dom - Domestic Animals - goat,sheep
Tissue Tested : itt - Intratesticular
Dose Data : 23 mg/kg
Source : IJEBA6 - Indian Journal of Experimental Biology
11:143, 1973
Mutation Test System : dna - DNA Adduct
Organism : mam - Mammal-species unspecified
Tissue Tested : lym - Lymphocyte
Dose Data : 500 ppm
Source : MOLBBJ - Molecular Biology. English translation of
Molekuliarnaia Biologiia 7:201, 1973
Mutation Test System : dnd - DNA Damage
Organism : mam - Mammal-species unspecified
Tissue Tested : lym - Lymphocyte
Dose Data : 660 mmol/L
Source : BIORAK - Biochemistry (English Translation).
Translation of BIOHAO 39:436, 1974
|
| REPRODUCTIVE DATA: |
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 168 mg/kg (1-21D preg)
Reproductive Effects : Specific Developmental Abnormalities : T51 -
Hepatobiliary system.
Source : GISAAA - Gigiena i Sanitariya. For English
translation, see HYSAAV 55(3):89, 1990
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 200 mg/kg (1D male)
Reproductive Effects : Paternal Effects : T01 - Spermatogenesis
(including genetic material, sperm morphology,
motility, and count).
Source : TJADAB - Teratology, The International Journal
of Abnormal Development 26(3):14A, 1982
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 168 mg/kg (1-21D preg)
Reproductive Effects : Effects on Newborn : T83 - Biochemical and
metabolic.
Source : GISAAA - Gigiena i Sanitariya. For English
translation, see HYSAAV 55(4):36, 1990
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 1 mg/m3/24H (1
22D preg)
Reproductive Effects : Effects on Embryo or Fetus : T33 - Cytological
changes (including somatic cell genetic
material).
Source : HYSAAV - Hygiene and Sanitation (USSR). English
translation of GISAAA 34(5):266, 1969
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 12 ug/m3/24H
(15D pre/1-22D preg)
Reproductive Effects : Effects on Newborn : T81 - Growth statistics
(e.g., reduced weight gain).; T87 - Other
postnatal measures or effects.
Source : HYSAAV - Hygiene and Sanitation (USSR). English
translation of GISAAA 33(1-3):327, 1968
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 12 ug/m3/24h (1
22D preg)
Reproductive Effects : Effects on Newborn : T83 - Biochemical and
metabolic.
Source : HYSAAV - Hygiene and Sanitation (USSR). English
translation of GISAAA 33(7-9):112, 1968
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 35 ug/m3/8H (60D
male)
Reproductive Effects : Paternal Effects : T01 - Spermatogenesis
(including genetic material, sperm morphology,
motility, and count).; T09 - Other effects on
male.
Source : PRKHDK - Problemi na Khigienata. Problems in
Hygiene 4:101, 1979
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 12 ug/m3/24H
(20D pre/1-22D preg)
Reproductive Effects : Effects on Newborn : T83 - Biochemical and
metabolic.
Source : BEXBAN - Bulletin of Experimental Biology and
Medicine (English Translation). Translation of
BEBMAE. (Plenum Pub. Corp., 233 Spring St., New
York, NY 10013) V.41- 1956- 66:868, 1968
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 500 ug/m3/4H (1
19D preg)
Reproductive Effects : Specific Developmental Abnormalities : T46 -
Musculoskeletal system. Effects on Newborn :
T85 - Behavioral.
Source : GISAAA - Gigiena i Sanitariya. For English
translation, see HYSAAV 56(9):35, 1991
Route of Administration : ipr - Intraperitoneal
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 80 mg/kg (10D male)
Reproductive Effects : Paternal Effects : T02 - Testes, epididymis,
sperm duct.; T03 - Prostate, seminal vessicle,
Cowper's gland, accessory glands.
Source : JRBED2 - Journal of Reproductive Biology and
Comparative Endocrinology 7:42, 1987
Route of Administration : scu - Subcutaneous
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 46243 mg/kg (20D male)
Reproductive Effects : Paternal Effects : T02 - Testes, epididymis,
sperm duct.
Source : ENDOAO - Endocrinology (Baltimore) 28:129, 1941
Route of Administration : itt - Intratesticular
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 400 mg/kg (1D male)
Reproductive Effects : Effects on Fertility : T23 - Male fertility
index (e.g., # males impregnating females per #
males exposed to fertile nonpregnant females).
Source : FESTAS - Fertility and Sterility 24:884, 1973
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 168 mg/kg (1-21D preg)
Reproductive Effects : Specific Developmental Abnormalities : T51 -
Hepatobiliary system.
Source : GISAAA - Gigiena i Sanitariya. For English
translation, see HYSAAV 54(3):89, 1989
Route of Administration : ipr - Intraperitoneal
Species Tested : mus - Mouse
Dose Data : TDLo - Toxic Dose Low: 240 mg/kg (7-14D preg)
Reproductive Effects : Effects on Embryo or Fetus : T34 - Fetotoxicity
(except death, e.g., stunted fetus). Specific
Developmental Abnormalities : T43 -
Craniofacial (including nose and tongue).; T46
- Musculoskeletal system.
Source : TJADAB - Teratology, The International Journal
of Abnormal Development 28:37A, 1983
Route of Administration : ipr - Intraperitoneal
Species Tested : mus - Mouse
Dose Data : TDLo - Toxic Dose Low: 240 mg/kg (7-14D preg)
Reproductive Effects : Effects on Embryo or Fetus : T35 - Fetal death.
Source : TJADAB - Teratology, The International Journal
of Abnormal Development 30(1):34A, 1984
Route of Administration : ipr - Intraperitoneal
Species Tested : mus - Mouse
Dose Data : TDLo - Toxic Dose Low: 160 mg/kg (7-14D preg)
Reproductive Effects : Specific Developmental Abnormalities : T59 -
Other developmental abnormalities.
Source : TJADAB - Teratology, The International Journal
of Abnormal Development 30(1):34A, 1984
Route of Administration : ipr - Intraperitoneal
Species Tested : mus - Mouse
Dose Data : TDLo - Toxic Dose Low: 500 mg/kg (5D male)
Reproductive Effects : Paternal Effects : T01 - Spermatogenesis
(including genetic material, sperm morphology,
motility, and count).
Source : MUREAV - Mutation Research 130:417, 1984
Route of Administration : ims - Intramuscular
Species Tested : mus - Mouse
Dose Data : TDLo - Toxic Dose Low: 259 mg/kg (11D preg)
Reproductive Effects : Effects on Fertility : T25 - Post-implantation
mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on
Embryo or Fetus : T35 - Fetal death.
Source : ANREAK - Anatomical Record 142:479, 1962
Route of Administration : itt - Intratesticular
Species Tested : dog - Dog, adult
Dose Data : TDLo - Toxic Dose Low: 7 mg/kg (1D male)
Reproductive Effects : Paternal Effects : T02 - Testes, epididymis,
sperm duct.
Source : AEFTAA - Acta Europaea Fertilitatis 6:349, 1975
Route of Administration : itt - Intratesticular
Species Tested : mky - Monkey
Dose Data : TDLo - Toxic Dose Low: 4 mg/kg (1D male)
Reproductive Effects : Paternal Effects : T01 - Spermatogenesis
(including genetic material, sperm morphology,
motility, and count).
Source : FESTAS - Fertility and Sterility 41:465, 1984
Route of Administration : itt - Intratesticular
Species Tested : dom - Domestic Animals - goat,sheep
Dose Data : TDLo - Toxic Dose Low: 6667 ug/kg (1D male)
Reproductive Effects : Paternal Effects : T01 - Spermatogenesis
(including genetic material, sperm morphology,
motility, and count).; T02 - Testes,
epididymis, sperm duct.
Source : IJEBA6 - Indian Journal of Experimental Biology
11:143, 1973
|
| TUMORIGENIC DATA: |
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 109 gm/kg/2Y-C
Tumorigenic Effects : V02 - Neoplastic; K60 - GASTROINTESTINAL
[Tumors]; P61 - BLOOD [Leukemia]
Source : TIHEEC - Toxicology and Industrial Health 5:699,
1989
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 14300 ppb/6H/2Y
I
Tumorigenic Effects : V02 - Neoplastic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : CNREA8 - Cancer Research 43:4382, 1983
Route of Administration : scu - Subcutaneous
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 1170 mg/kg/65W-I
Tumorigenic Effects : V01 - Carcinogenic; V10 - TUMORIGENIC [Tumors
at site of application]
Source : GANNA2 - Gann. Japanese Journal of Cancer
Research 45:451, 1954
Route of Administration : ihl - Inhalation
Species Tested : mus - Mouse
Dose Data : TCLo - Toxic Concentration Low: 14300 ppb/6H/2Y
I
Tumorigenic Effects : V01 - Carcinogenic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : CNREA8 - Cancer Research 43:4382, 1983
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 15 ppm/6H/78W-I
Tumorigenic Effects : V02 - Neoplastic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : CNREA8 - Cancer Research 40:3398, 1980
Route of Administration : scu - Subcutaneous
Species Tested : Rat
Dose Data : TD - Toxic Dose: 350 mg/kg/78W-I
Tumorigenic Effects : V01 - Carcinogenic; R60 - SKIN AND APPENDAGES:
Other [Tumors]; V10 - TUMORIGENIC [Tumors at
site of application]
Source : FAONAU - FAO Nutrition Meetings Report Series
50A:71, 1972
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 6 ppm/6H/2Y-I
Tumorigenic Effects : V01 - Carcinogenic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : EVSRBT - Environmental Science Research 25:353,
1982
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 15 ppm/6H/86W-I
Tumorigenic Effects : V02 - Neoplastic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : TXAPA9 - Toxicology and Applied Pharmacology
81:401, 1985
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 14 ppm/6H/84W-I
Tumorigenic Effects : V02 - Neoplastic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : JJIND8 - JNCI, Journal of the National Cancer
Institute 68:597, 1982
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 18750 ug/m3/2Y-I
Tumorigenic Effects : V01 - Carcinogenic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : GISAAA - Gigiena i Sanitariya. For English
translation, see HYSAAV 48(4):60, 1983
Route of Administration : ihl - Inhalation
Species Tested : mus - Mouse
Dose Data : TC - Toxic Concentration: 15 ppm/6H/104W-I
Tumorigenic Effects : V01 - Carcinogenic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : EVSRBT - Environmental Science Research 25:353,
1982
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 15 ppm/6H/2Y-I
Tumorigenic Effects : V02 - Neoplastic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : CIIT** - Chemical Industry Institute of
Toxicology, Docket Reports. (POB 12137,
Research Triangle Park, NC 27709) DOCKET
#10992:1982
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 5600 ppb/6H/2Y-I
Tumorigenic Effects : V01 - Carcinogenic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : CNREA8 - Cancer Research 43:4382, 1983
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TC - Toxic Concentration: 14300 ppb/6H/2Y-I
Tumorigenic Effects : V01 - Carcinogenic; D09 - SENSE ORGANS AND
SPECIAL SENSES (NOSE, EYE, EAR, AND TASTE):
Olfaction [Tumors]
Source : 50EXAK - "Formaldehyde Toxicity, Conference,
1980," Gibson, J.E., ed., New York, NY,
Hemisphere Pub. Corp., 1983 p.111 1983
|
| ACUTE TOXICITY DATA: |
Route of Administration : orl - Oral
Species Tested : Man
Dose Data : TDLo - Toxic Dose Low: 643 mg/kg
Toxic Effects : J20 - LUNGS, THORAX, OR RESPIRATION [Respiratory
obstruction]; K06 - GASTROINTESTINAL
[Ulceration or bleeding from stomach]; K13 -
GASTROINTESTINAL [Nausea or vomiting]
Source : JJTOEX - Japanese Journal of Toxicology 4:261,
1991
Route of Administration : orl - Oral
Species Tested : wmn - Woman
Dose Data : LDLo - Lethal Dose Low: 108 mg/kg
Toxic Effects : None applicable
Source : 29ZWAE - "Practical Toxicology of Plastics,"
Lefaux, R., Cleveland, OH, Chemical Rubber Co.,
1968 p.328 1968
Route of Administration : ihl - Inhalation
Species Tested : hmn - Human
Dose Data : TCLo - Toxic Concentration Low: 17 mg/m3/30M
Toxic Effects : D17 - SENSE ORGANS AND SPECIAL SENSES (NOSE,
EYE, EAR, AND TASTE): Eye [Lacrimation]; J30 -
LUNGS, THORAX, OR RESPIRATION [Other changes]
Source : JAMAAP - JAMA, Journal of the American Medical
Association 165:1908, 1957
Route of Administration : orl - Oral
Species Tested : Man
Dose Data : TDLo - Toxic Dose Low: 646 mg/kg
Toxic Effects : K05 - GASTROINTESTINAL [Gastritis]; K06 -
GASTROINTESTINAL [Ulceration or bleeding from
stomach]; K13 - GASTROINTESTINAL [Nausea or
vomiting]
Source : JJTOEX - Japanese Journal of Toxicology 4:261,
1991
Route of Administration : orl - Oral
Species Tested : wmn - Woman
Dose Data : LDLo - Lethal Dose Low: 1 mL/kg
Toxic Effects : F24 - BEHAVIORAL [Coma]; G30 - CARDIAC [Other
changes]; K04 - GASTROINTESTINAL [Alteration
in gastric secretion]
Source : ICMED9 - Intensive Care Medicine 23:708, 1997
Route of Administration : ihl - Inhalation
Species Tested : Man
Dose Data : TCLo - Toxic Concentration Low: 300 ug/m3
Toxic Effects : D07 - SENSE ORGANS AND SPECIAL SENSES (NOSE,
EYE, EAR, AND TASTE): Olfaction [Other changes]
; F43 - BEHAVIORAL [Aggression]
Source : GTPZAB - Gigiena Truda i Professional'nye
Zabolevaniya. Labor Hygiene and Occupational
Diseases. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1-36, 1957-1992. For publisher
information, see MTPEEI 12(7):20, 1968
Route of Administration : unr - Unreported
Species Tested : Man
Dose Data : LDLo - Lethal Dose Low: 477 mg/kg
Toxic Effects : None applicable
Source : 85DCAI - "Poisoning; Toxicology, Symptoms,
Treatments," 2nd ed., Arena, J.M., Springfield,
IL, C.C. Thomas, 1970 2,73,1970
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : LD50 - Lethal Dose 50%: 100 mg/kg
Toxic Effects : None applicable
Source : FCTOD7 - Food and Chemical Toxicology 26:447,
1988
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : LC50 - Lethal Concentration 50%: 203 mg/m3
Toxic Effects : C06 - PERIPHERAL NERVE AND SENSATION [Spastic
paralysis with or without sensory change]; F12
- BEHAVIORAL [Convulsions or effect on seizure
theshold]; F13 - BEHAVIORAL [Excitement]
Source : GTPZAB - Gigiena Truda i Professional'nye
Zabolevaniya. Labor Hygiene and Occupational
Diseases. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1-36, 1957-1992. For publisher
information, see MTPEEI 18(2):55, 1974
Route of Administration : scu - Subcutaneous
Species Tested : Rat
Dose Data : LD50 - Lethal Dose 50%: 420 mg/kg
Toxic Effects : J15 - LUNGS, THORAX, OR RESPIRATION [Acute
pulmonary edema]; J04 - LUNGS, THORAX, OR
RESPIRATION [Bronchiolar constriction]
Source : APTOA6 - Acta Pharmacologica et Toxicologica
6:299, 1950
Route of Administration : ivn - Intravenous
Species Tested : Rat
Dose Data : LD50 - Lethal Dose 50%: 87 mg/kg
Toxic Effects : None applicable
Source : AEPPAE - Naunyn-Schmiedeberg's Archiv fuer
Experimentelle Pathologie und Pharmakologie
221:166, 1954
Route of Administration : orl - Oral
Species Tested : mus - Mouse
Dose Data : LD50 - Lethal Dose 50%: 42 mg/kg
Toxic Effects : F07 - BEHAVIORAL [Somnolence (general depressed
activity)]; F12 - BEHAVIORAL [Convulsions or
effect on seizure theshold]; F13 - BEHAVIORAL
[Excitement]
Source : NTIS** - National Technical Information Service.
(Springfield, VA 22161) Formerly U.S.
Clearinghouse for Scientific & Technical
Information. AD-A125-539
Route of Administration : ihl - Inhalation
Species Tested : mus - Mouse
Dose Data : LC50 - Lethal Concentration 50%: 454 gm/m3/4H
Toxic Effects : None applicable
Source : CUTOEX - Current Toxicology 1:47, 1993
Route of Administration : ipr - Intraperitoneal
Species Tested : mus - Mouse
Dose Data : LDLo - Lethal Dose Low: 16 mg/kg
Toxic Effects : None applicable
Source : TXAPA9 - Toxicology and Applied Pharmacology
23:288, 1972
Route of Administration : scu - Subcutaneous
Species Tested : mus - Mouse
Dose Data : LD50 - Lethal Dose 50%: 300 mg/kg
Toxic Effects : J15 - LUNGS, THORAX, OR RESPIRATION [Acute
pulmonary edema]; J04 - LUNGS, THORAX, OR
RESPIRATION [Bronchiolar constriction]
Source : APTOA6 - Acta Pharmacologica et Toxicologica
6:299, 1950
Route of Administration : scu - Subcutaneous
Species Tested : dog - Dog, adult
Dose Data : LDLo - Lethal Dose Low: 350 mg/kg
Toxic Effects : None applicable
Source : IPSTB3 - International Polymer Science and
Technology 3:93, 1976
Route of Administration : ivn - Intravenous
Species Tested : dog - Dog, adult
Dose Data : LDLo - Lethal Dose Low: 70 mg/kg
Toxic Effects : None applicable
Source : IPSTB3 - International Polymer Science and
Technology 3:93, 1976
Route of Administration : ihl - Inhalation
Species Tested : cat - Cat, adult
Dose Data : LCLo - Lethal Concentration Low: 400 mg/m3/2H
Toxic Effects : None applicable
Source : 85GMAT - "Toxicometric Parameters of Industrial
Toxic Chemicals Under Single Exposure,"
Izmerov, N.F., et al., Moscow, Centre of
International Projects, GKNT, 1982 p.69 1982
Route of Administration : ivn - Intravenous
Species Tested : cat - Cat, adult
Dose Data : LDLo - Lethal Dose Low: 30 mg/kg
Toxic Effects : P30 - BLOOD [Other changes]
Source : APTOA6 - Acta Pharmacologica et Toxicologica
8:275, 1952
Route of Administration : skn - Skin
Species Tested : rbt - Rabbit, adult
Dose Data : LD50 - Lethal Dose 50%: 270 uL/kg
Toxic Effects : None applicable
Source : UCDS** - Union Carbide Data Sheet. (Union
Carbide Corp., 39 Old Ridgebury Rd., Danbury,
CT 06817) 4/21/1967
Route of Administration : scu - Subcutaneous
Species Tested : rbt - Rabbit, adult
Dose Data : LDLo - Lethal Dose Low: 240 mg/kg
Toxic Effects : Y55 - BIOCHEMICAL: Metabolism (intermediary)
[Effect on inflammation or mediation of
inflammation]
Source : JAMAAP - JAMA, Journal of the American Medical
Association 62:984, 1914
Route of Administration : ivn - Intravenous
Species Tested : rbt - Rabbit, adult
Dose Data : LDLo - Lethal Dose Low: 48 mg/kg
Toxic Effects : None applicable
Source : ARZNAD - Arzneimittel-Forschung. Drug Research
5:213, 1955
Route of Administration : orl - Oral
Species Tested : gpg - Guinea pig, adult
Dose Data : LD50 - Lethal Dose 50%: 260 mg/kg
Toxic Effects : None applicable
Source : JIHTAB - Journal of Industrial Hygiene and
Toxicology 23:259, 1941
Route of Administration : par - Parenteral
Species Tested : frg - Frog, adult
Dose Data : LDLo - Lethal Dose Low: 800 ug/kg
Toxic Effects : None applicable
Source : IPSTB3 - International Polymer Science and
Technology 3:93, 1976
|
| OTHER MULTIPLE DOSE TOXICITY DATA: |
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 3500 mg/kg/4W-C
Toxic Effects : F15 - BEHAVIORAL [Food intake (animal)]; M70 -
KIDNEY, URETER, BLADDER [Changes in bladder
weight]]; Y39 - BIOCHEMICAL: Metabolism
(intermediary) [Plasma proteins not involving
coagulation]
Source : FCTOD7 - Food and Chemical Toxicology 26:447,
1988
Route of Administration : orl - Oral
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 60 gm/kg/2Y-C
Toxic Effects : K05 - GASTROINTESTINAL [Gastritis]; K06 -
GASTROINTESTINAL [Ulceration or bleeding from
stomach]; M30 - KIDNEY, URETER, BLADDER [Other
changes]
Source : FCTOD7 - Food and Chemical Toxicology 27:77,
1989
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 15 ppm/6H/24W-I
Toxic Effects : J30 - LUNGS, THORAX, OR RESPIRATION [Other
changes]; U01 - NUTRITIONAL AND GROSS
METABOLIC [Weight loss or decreased weight
gain]; Y12 - BIOCHEMICAL: Enzyme inhibition,
induction, or change in blood or tissue levels
[Other oxidoreductases]
Source : ENVRAL - Environmental Research 49:50, 1989
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 4 ppm/30M/13W-I
Toxic Effects : D07 - SENSE ORGANS AND SPECIAL SENSES (NOSE,
EYE, EAR, AND TASTE): Olfaction [Other changes]
Source : TOLED5 - Toxicology Letters 47:287, 1989
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 99 ppm/6H/30D-I
Toxic Effects : P72 - BLOOD [Changes in leukocyte (WBC) count];
S04 - IMMUNOLOGICAL INCLUDING ALLERGIC
[Decrease in humoral immune response]; U01 -
NUTRITIONAL AND GROSS METABOLIC [Weight loss or
decreased weight gain]
Source : TOXID9 - Toxicologist 3:73, 1983
Route of Administration : ihl - Inhalation
Species Tested : Rat
Dose Data : TCLo - Toxic Concentration Low: 3200 ppb/6H/3D-I
Toxic Effects : D07 - SENSE ORGANS AND SPECIAL SENSES (NOSE,
EYE, EAR, AND TASTE): Olfaction [Other changes]
; Y12 - BIOCHEMICAL: Enzyme inhibition,
induction, or change in blood or tissue levels
[Other oxidoreductases]
Source : FAATDF - Fundamental and Applied Toxicology
29:208, 1996
Route of Administration : ivn - Intravenous
Species Tested : Rat
Dose Data : TDLo - Toxic Dose Low: 2730 mg/kg/13W-I
Toxic Effects : L70 - LIVER [Changes in liver weight]; N72 -
ENDOCRINE [Changes in adrenal weight]; N74 -
ENDOCRINE [Changes in thymus weight]
Source : IYKEDH - Iyakuhin Kenkyu. Study of Medical
Supplies 24:1175, 1993
Route of Administration : ihl - Inhalation
Species Tested : mus - Mouse
Dose Data : TCLo - Toxic Concentration Low: 40 ppm/6H/13W-I
Toxic Effects : Z01 - RELATED TO CHRONIC DATA [Death in the "U"
data type field]
Source : TXCYAC - Toxicology 41:253, 1986
|
| STANDARDS & REGULATIONS: |
Regulation : Environmental Protection Agency [EPA];
Federal Insecticide, Fungicide, and
Rfodenticide Act [FIFRA]
EPA/FIFRA Standard : 1988 PESTICIDE SUBJECT TO REGISTRATION
OR RE-REGISTRATION
Source : FEREAC - Federal Register 54:7740, 1989
Regulation : Federal Mine Safety and Health Act of
1970 [MSHA]
Mine Safety and Health Standard : air-CL 2 ppm (3 mg/m3)
Source : DTLWS* - "Documentation of the Threshold
Limit Values for Substances in Workroom
Air," Supplements. For publisher
information, see 85INA8. 3:19, 1973
Regulation : Occupational Safety and Health Actof
1977 [OSHA]; Occupational Safety and
Health Administration
Industry : General Industry; Gen Indu
OSHA Air Contaminant Standard : see 1910.1048
Source : CFRGBR - Code of Federal Regulations
29:1910.1000, 1994
Regulation : Occupational Safety and Health Actof
1977 [OSHA]; Occupational Safety and
Health Administration
Industry : Construction [Construc]
OSHA Air Contaminant Standard : see CFR 29,1926.1148
Source : CFRGBR - Code of Federal Regulations
29:1926.55, 1994
Regulation : Occupational Safety and Health Actof
1977 [OSHA]; Occupational Safety and
Health Administration
Industry : Federal Contractor [Fed Cont]
OSHA Air Contaminant Standard : Ceiling 5 ppm (6 mg/m3)
Source : CFRGBR - Code of Federal Regulations
41:50-204.50, 1994
Regulation : International Occupational Exposure
Limits
OEL Country : ARAB Republic of Egypt
Occupational Exposure Limit : Time-weighted average [TWA]: 2 ppm (3
mg/m3), JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : AUSTRALIA
Occupational Exposure Limit : Time-weighted average [TWA]: 1 ppm (1.5
mg/m3), Short-term exposure limit
[STEL]: 2 ppm, Carcinogen, JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : AUSTRIA
Occupational Exposure Limit : MAK 0.5 ppm (0.6 mg/m3), Suspected
Carcinogen, JAN1999
Regulation : International Occupational Exposure
Limits
OEL Country : BELGIUM
Occupational Exposure Limit : Time-weighted average [TWA]: 1 ppm (1.2
mg/m3), Short-term exposure limit
[STEL]: 2 ppm, Carcinogen, JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : DENMARK
Occupational Exposure Limit : Time-weighted average [TWA]: 0.3 ppm
(0.4 mg/m3), JAN1999
Regulation : International Occupational Exposure
Limits
OEL Country : FRANCE
Occupational Exposure Limit : VME 0.5 ppm, VLE 1 ppm, C3 Carcinogen,
JAN1999
Regulation : International Occupational Exposure
Limits
OEL Country : GERMANY
Occupational Exposure Limit : MAK 0.5 ppm (0.6 mg/m3), Carcinogen,
JAN1999
Regulation : International Occupational Exposure
Limits
OEL Country : HUNGARY
Occupational Exposure Limit : Short-term exposure limit [STEL]: 0.6
mg/m3, Carcinogen, JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : JAPAN
Occupational Exposure Limit : OEL 0.5 ppm (0.61 mg/m3), 2A Carcinogen,
JAN1999
Regulation : International Occupational Exposure
Limits
OEL Country : THE NETHERLANDS
Occupational Exposure Limit : MAC-TGG 1 ppm (1.5 mg/m3), MAC-K 2 ppm
(3 mg/m3), J
Regulation : International Occupational Exposure
Limits
OEL Country : NORWAY
Occupational Exposure Limit : Time-weighted average [TWA]: 0.5 ppm
(0.6 mg/m3), JAN1999
Regulation : International Occupational Exposure
Limits
OEL Country : THE PHILIPPINES
Occupational Exposure Limit : Time-weighted average [TWA]: 5 ppm (6
mg/m3), JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : POLAND
Occupational Exposure Limit : MAC(Time-weighted average [TWA]:) 0.5
mg/m3, MAC(Short-term exposure limit
[STEL]:) 1 mg/m3, JAN1999
Regulation : International Occupational Exposure
Limits
OEL Country : RUSSIA
Occupational Exposure Limit : Time-weighted average [TWA]: 0.5 ppm,
Short-term exposure limit [STEL]: 0.5
mg/m3, Skin, JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : SWEDEN
Occupational Exposure Limit : NGV 0.5 ppm (0.6 mg/m3), TGV 1 ppm (1.2
mg/m3), Skin, JAN199
Regulation : International Occupational Exposure
Limits
OEL Country : SWITZERLAND
Occupational Exposure Limit : MAK-W 0.5 ppm (0.6 mg/m3), KZG-W 1 ppm
(1.2 mg/m3), JAN
Source : AN1999
Regulation : International Occupational Exposure
Limits
OEL Country : THAILAND
Occupational Exposure Limit : Time-weighted average [TWA]: 3 ppm,
Short-term exposure limit [STEL]: 5
ppm, JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : TURKEY
Occupational Exposure Limit : Time-weighted average [TWA]: 5 ppm (6
mg/m3), JAN1993
Regulation : International Occupational Exposure
Limits
OEL Country : UNITED KINGDOM
Occupational Exposure Limit : LTEL 2 ppm (2.5 mg/m3), Short-term
exposure limit [STEL]: 2 ppm (2.5
mg/m3), JAN1
Regulation : OEL IN ARGENTINA, BULGARIA, COLOMBIA,
JORDAN, KOREA check ACGIH TLV;
Regulation : OEL IN NEW ZEALAND, SINGAPORE, VIETNAM
check ACGIH TLV
|
| NIOSH DOCUMENTATION &
SURVEILLANCE DATA: |
National Occupational Hazard Survey [NOHS] 1974
HAZARD CODE [HZD] : M1529
NUMBER OF INDUSTRIES [NIS] : 72
TOTAL NUMBER OF FACILITIES [TNF] : 10311
NUMBER OF OCCUPATIONS [NOS] : 67
TOTAL NUMBER OF EMPLOYEES EXPOSED [TNE] : 66921
National Occupational Hazard Survey [NOHS] 1974
HAZARD CODE [HZD] : 33640
NUMBER OF INDUSTRIES [NIS] : 213
TOTAL NUMBER OF FACILITIES [TNF] : 33243
NUMBER OF OCCUPATIONS [NOS] : 155
TOTAL NUMBER OF EMPLOYEES EXPOSED [TNE] : 394660
National Occupational Exposure Survey [NOES] 1983
HAZARD CODE [HZD] : M1529
NUMBER OF INDUSTRIES [NIS] : 87
TOTAL NUMBER OF FACILITIES [TNF] : 11309
NUMBER OF OCCUPATIONS [NOS] : 69
TOTAL NUMBER OF EMPLOYEES EXPOSED [TNE] : 207013
TOTAL NUMBER OF FEMALE EMPLOYEES EXPOSED [TFE] : 104994
National Occupational Exposure Survey [NOES] 1983
HAZARD CODE [HZD] : 33640
NUMBER OF INDUSTRIES [NIS] : 309
TOTAL NUMBER OF FACILITIES [TNF] : 65738
NUMBER OF OCCUPATIONS [NOS] : 193
TOTAL NUMBER OF EMPLOYEES EXPOSED [TNE] : 1329322
TOTAL NUMBER OF FEMALE EMPLOYEES EXPOSED [TFE] : 441902
|
| NIOSH RECOMMENDED EXPOSURE LEVEL: |
NIOSH Recommended Exposure Level to FORMALDEHYDE-air:8H CA TWA 0.016 ppm
CL 0.1 ppm/15M Source: NIOSH* DHHS #92-100,199
|
| STATUS: |
EPA GENETOX Program(1988)
GENETOX Evidence : Positive
GENETOX Method : Carcinogenicity-mouse/rat
EPA GENETOX Program(1988)
GENETOX Evidence : Positive
GENETOX Method : D melanogaster-reciprocal translocation
EPA GENETOX Program(1988)
GENETOX Evidence : Positive
GENETOX Method : N crassa-reversion; E coli polA without S9
EPA GENETOX Program(1988)
GENETOX Evidence : Positive
GENETOX Method : D melanogaster Sex-linked lethal
EPA GENETOX Program(1988)
GENETOX Evidence : Positive
GENETOX Method : S cerevisiae gene conversion; S cerevisiae
reversion
EPA GENETOX Program(1988)
GENETOX Evidence : Inconclusive
GENETOX Method : In vitro UDS-human fibroblast
EPA GENETOX Program(1988)
GENETOX Evidence : Inconclusive
GENETOX Method : CHO gene mutation
EPA TSCA: Section 8(b) [chemical inventory section]
EPA TSCA Section 8(d)[unpublished health/safety studies]
EPA IRIS Database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JULY 2000
NIOSH Current Intelligence Bulletin 34, APRIL 1981
NIOSH Analytical Method 1994
Aldehydes, screening, 2539
NIOSH Analytical Method 1994
Formaldehyde by on dust (textile or wood), 5700
NIOSH Analytical Method 1994
Formaldehyde by GC, 2541; by VIS, 3500
NTP 9th Report on Carcinogens,2000:Reasonably anticipated to be human
carcinogen
OSHA ANALYTICAL METHOD #ID-102
|
| REVIEWS: |
Review Type : Threshold Limit Value / TLV
Threshold Limit Value : Suspected human carcinogen
Source : DTLVS* - The Threshold Limit Values (TLVs)
and Biological Exposure Indices (BEIs)
booklet issued by American Conference of
Governmental Industrial Hygienists (ACGIH),
Cincinnati, OH, 1996 TLV/BEI:1999
Review Type : Threshold Limit Value / TLV
Threshold Limit Value : CL 0.3 ppm
Source : DTLVS* - The Threshold Limit Values (TLVs)
and Biological Exposure Indices (BEIs)
booklet issued by American Conference of
Governmental Industrial Hygienists (ACGIH),
Cincinnati, OH, 1996 TLV/BEI:1999
Review Type : IARC Cancer Review
Evidence of Carcinogenicity: Animal Sufficient Evidence
Source : IMEMDT - IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man
29:345, 1982
Review Type : IARC Cancer Review
Evidence of Carcinogenicity: Animal Sufficient Evidence
Source : IMEMDT - IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man
62:217, 1995
Review Type : IARC Cancer Review
Evidence of Carcinogenicity: Human Limited Evidence
Source : IMSUDL - IARC Monographs, Supplement 7:211,
1987
Review Type : IARC Cancer Review
Evidence of Carcinogenicity: Human Limited Evidence
Source : IMEMDT - IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man
62:217, 1995
Review Type : IARC Cancer Review
Evidence of Carcinogenicity: Group 2A
Source : IMSUDL - IARC Monographs, Supplement 7:211,
1987
Review Type : IARC Cancer Review
Evidence of Carcinogenicity: Group 2A
Source : IMEMDT - IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man
62:217, 1995
Review Type : Toxicology Review
Source : EVHPAZ - EHP, Environmental Health
Perspectives 11:163, 1975
Review Type : Toxicology Review
Source : CMTVAS - Cahiers de Medecine du Travail
10(3):49, 1973
Review Type : Toxicology Review
Source : 32XPAD - "Teratology," Berry, C.L., and D.E.
Poswillo, eds., New York, Springer, 1975
p.49 1975
|
| CIS RECORD ID.: RTEC-0060146 |
| YEAR/MONTH LAST CHANGED: 200007 |