Effect of ondansetron on the analgesic efficacy of tramadol used for postoperative analgesia: a randomised controlled study

Abstract

Background: Ondansetron is used to reduce tramadol induced postoperative nausea and vomiting (PONV). Studies on patient-controlled analgesia (PCA) found that ondansetron reduces the analgesic efficacy of tramadol. Drug requirement in PCA and in conventional intravenous analgesia without PCA device may differ. This study evaluated the effect of ondansetron on analgesic efficacy of tramadol for postoperative analgesia without a PCA device.