A prospective, randomised, controlled clinical trial to evaluate the effect of nitrous oxide on propofol requirement in elective craniotomy in which entropy was used to measure depth of anaesthesia

Abstract

Background: Propofol is known to have a favourable effect on cerebral haemodynamics. The role of nitrous oxide (N₂O) in neurosurgical anaesthesia is still being debated. The primary aim of this study was to assess the dose-sparing effect of N₂O on propofol infusion maintenance dosing.